2,946 research outputs found
Excipient-free inhalable microparticles of Azithromycin produced by electrospray: A novel approach to direct pulmonary delivery of antibiotics
Inhalation therapy offers several advantages in respiratory disease treatment. Azithromycin is a macrolide antibiotic with poor solubility and bioavailability but with a high potential to be used to fight lung infections. The main objective of this study was to generate a new inhalable dry powder azithromycin formulation. To this end, an electrospray was used, yielding a particle size around 2.5 ”m, which is considered suitable to achieve total deposition in the respiratory system. The physicochemical properties and morphology of the obtained microparticles were analysed with a battery of characterization techniques. In vitro deposition assays were evaluated after aerosolization of the powder at constant flow rate (100 L/min) and the consideration of the simulation of two different realistic breathing profiles (healthy and chronic obstructive pulmonary disease (COPD) patients) into a next generation impactor (NGI). The formulation was effective in vitro against two types of bacteria, Staphylococcus aureus and Pseudomonas aeruginosa. Finally, the particles were biocompatible, as evidenced by tests on the alveolar cell line (A549) and bronchial cell line (Calu-3). © 2021 by the authors. Licensee MDPI, Basel, Switzerland
The Effect of Wildfire on Soil Mercury Concentrations in Southern California Watersheds
Mercury (Hg) stored in vegetation and soils is known to be released to the atmosphere during wildfires, increasing atmospheric stores and altering terrestrial budgets. Increased erosion and transport of sediments is well-documented in burned watersheds, both immediately post-fire and as the watershed recovers; however, understanding post-fire mobilization of soil Hg within burned watersheds remains elusive. The goal of the current study is to better understand the impact of wildfire on soil-bound Hg during the immediate post-fire period as well as during recovery, in order to assess the potential for sediment-driven transport to and within surface waters in burned watersheds. Soils were collected from three southern California watersheds of similar vegetation and soil characteristics that experienced wildfire. Sampling in one of these watersheds was extended for several seasons (1.5 years) in order to investigate temporal changes in soil Hg concentrations. Laboratory analysis included bulk soil total Hg concentrations and total organic carbon of burned and unburned samples. Soils were also fractionated into a subset of grain sizes with analysis of Hg on each fraction. Low Hg concentrations were observed in surface soils immediately post-fire. Accumulation of Hg coincident with moderate vegetative recovery was observed in the burned surface soils 1 year following the fire, and mobilization was also noted during the second winter (rainy) season. Hg concentrations were highest in the fine-grained fraction of unburned soils; however, in the burned soils, the distribution of soil-bound Hg was less influenced by grain size. The accelerated accumulation of Hg observed in the burned soils, along with the elevated risk of erosion, could result in increased delivery of organic- or particulate-bound Hg to surface waters in post-fire systems
Design of a nasal spray based on cardiospermum halicacabum extract loaded in phospholipid vesicles enriched with gelatin or chondroitin sulfate
The extract of Cardiospermum halicacabum L. (C. halicacabum) obtained from flower, leaf and vine was loaded into modified phospholipid vesicles aiming at obtaining sprayable, biocompatible and effective nasal spray formulations for the treatment of nasopharyngeal diseases. Penetration enhancer-containing vesicles (PEVs) and hyalurosomes were formulated, and stabilized by adding a commercial gelatin from fish (20 mg/mL) or chondroitin sulfate from catshark cartilages (Scyliorhi-nus canicula, 20 mg/mL). Cryo-TEM images confirmed the formation of spherical vesicles, while photon correlation spectroscopy analysis disclosed the formation of small and negatively-charged vesicles. PEVs were the smaller vesicles (~100 nm) along with gelatin-hyalurosomes (~120 nm), while chondroitin-PEVs and chondroitin-hyalurosomes were larger (~160 nm). Dispersions prepared with chondroitin sulfate were more homogeneous, as the polydispersity index was ~0.15. The in vitro analysis of the droplet size distribution, average velocity module and spray cone angle suggested a good spray-ability and deposition of formulations in the nasal cavity, as the mean diameter of the droplets was in the range recommended by the Food and Drug Administration for nasal targets. The spray plume analysis confirmed the ability of PEVs, gelatin-PEVs, hyalurosomes and gelatin-hyalurosomes to be atomized in fine droplets homogenously distributed in a full cone plume, with an angle ranging from 25 to 30⊠. Moreover, vesicles were highly biocompatible and capable of protecting the epithelial cells against oxidative damage, thus preventing the inflammatory state
The effects of spatial resolution on Integral Field Spectrograph surveys at different redshifts. The CALIFA perspective
Over the past decade, 3D optical spectroscopy has become the preferred tool
for understanding the properties of galaxies and is now increasingly used to
carry out galaxy surveys. Low redshift surveys include SAURON, DiskMass,
ATLAS3D, PINGS and VENGA. At redshifts above 0.7, surveys such as MASSIV, SINS,
GLACE, and IMAGES have targeted the most luminous galaxies to study mainly
their kinematic properties. The on-going CALIFA survey () is the
first of a series of upcoming Integral Field Spectroscopy (IFS) surveys with
large samples representative of the entire population of galaxies. Others
include SAMI and MaNGA at lower redshift and the upcoming KMOS surveys at
higher redshift. Given the importance of spatial scales in IFS surveys, the
study of the effects of spatial resolution on the recovered parameters becomes
important. We explore the capability of the CALIFA survey and a hypothetical
higher redshift survey to reproduce the properties of a sample of objects
observed with better spatial resolution at lower redshift. Using a sample of
PINGS galaxies, we simulate observations at different redshifts. We then study
the behaviour of different parameters as the spatial resolution degrades with
increasing redshift.Comment: 20 pages, 16 figures. Accepted for publication in A&
Ionized gas kinematics of galaxies in the CALIFA survey I: Velocity fields, kinematic parameters of the dominant component, and presence of kinematically distinct gaseous systems
This work provides an overall characterization of the kinematic behavior of
the ionized gas of the galaxies included in the Calar Alto Legacy Integral
field Area (CALIFA), offering kinematic clues to potential users of this survey
for including kinematical criteria for specific studies. From the first 200
galaxies observed by CALIFA, we present the 2D kinematic view of the 177
galaxies satisfying a gas detection threshold. After removing the stellar
contribution, we used the cross-correlation technique to obtain the radial
velocity of the dominant gaseous component. The main kinematic parameters were
directly derived from the radial velocities with no assumptions on the internal
motions. Evidence of the presence of several gaseous components with different
kinematics were detected by using [OIII] profiles. Most objects in the sample
show regular velocity fields, although the ionized-gas kinematics are rarely
consistent with simple coplanar circular motions. 35% of the objects present
evidence of a displacement between the photometric and kinematic centers larger
than the original spaxel radii. Only 17% of the objects in the sample exhibit
kinematic lopsidedness when comparing receding and approaching sides of the
velocity fields, but most of them are interacting galaxies exhibiting nuclear
activity. Early-type galaxies in the sample present clear photometric-kinematic
misaligments. There is evidence of asymmetries in the emission line profiles
suggesting the presence of kinematically distinct gaseous components at
different distances from the nucleus. This work constitutes the first
determination of the ionized gas kinematics of the galaxies observed in the
CALIFA survey. The derived velocity fields, the reported kinematic
peculiarities and the identification of the presence of several gaseous
components might be used as additional criteria for selecting galaxies for
specific studies.Comment: 38 pages, 16 figures, 4 tables. Paper accepted for publication in A&
Imprints of galaxy evolution on H ii regions Memory of the past uncovered by the CALIFA survey
H ii regions in galaxies are the sites of star formation and thus particular
places to understand the build-up of stellar mass in the universe. The line
ratios of this ionized gas are frequently used to characterize the ionization
conditions. We use the Hii regions catalogue from the CALIFA survey (~5000 H ii
regions), to explore their distribution across the classical [OIII]/Hbeta vs.
[NII]/Halpha diagnostic diagram, and how it depends on the oxygen abundance,
ionization parameter, electron density, and dust attenuation. We compared the
line ratios with predictions from photoionization models. Finally, we explore
the dependences on the properties of the host galaxies, the location within
those galaxies and the properties of the underlying stellar population. We
found that the location within the BPT diagrams is not totally predicted by
photoionization models. Indeed, it depends on the properties of the host
galaxies, their galactocentric distances and the properties of the underlying
stellar population. These results indicate that although H ii regions are short
lived events, they are affected by the total underlying stellar population. One
may say that H ii regions keep a memory of the stellar evolution and chemical
enrichment that have left an imprint on the both the ionizing stellar
population and the ionized gasComment: 18 pages, 8 figures, accepted for publishing in A&
Extraction, characterization and incorporation of Hypericum scruglii extract in ad hoc formulated phospholipid vesicles designed for the treatment of skin diseases connected with oxidative stress
An extract of Hypericum scruglii, an endangered endemic plant of Sardinia (Italy), was prepared and characterized. It was loaded in special phospholipid vesicles, glycerosomes, which were modified by adding maltodextrin (glucidex) and a polymer (gelatin or hyaluronan). The corresponding liposomes were also prepared and used as reference. The vesicles disclosed suitable physicochemical features for skin delivery. Indeed, their mean diameter ranged from 120 to 160 nm, they were homogeneously dispersed (polydispersity index 0.30), and their zeta potential was highly negative (-45 mV). The vesicle dispersions maintained unchanged characteristics during 60 days of storage, were highly biocompatible, and were able to protect keratinocytes against damages due to oxidative stress induced by treating them with hydrogen peroxide. Vesicles were also capable of promoting cell proliferation and migration in vitro by means of a scratch wound assay. The results confirmed the fruitful delivery of the extract of H. scruglii in glycerosomes modified with glucidex and gelatin and their promising ability for skin protection and treatment
QED Logarithms in the Electroweak Corrections to the Muon Anomalous Magnetic Moment
We employ an effective Lagrangian approach to derive the leading-logarithm
two-loop electroweak contributions to the muon anomalous magnetic moment, a_mu.
We show that these corrections can be obtained using known results on the
anomalous dimensions of composite operators. We confirm the result of Czarnecki
et al. for the bosonic part and present the complete sin^2 \theta_W dependence
of the fermionic contribution. The approach is then used to compute the
leading-logarithm three-loop electroweak contribution to a_mu. Finally we
derive, in a fairly model-independent way, the QED improvement of new-physics
contributions to a_mu and to the electric dipole moment (EDM) of the electron.
We find that the QED corrections reduce the effect of new physics at the
electroweak scale by 6% (for a_mu) and by 11% (for the electron EDM).Comment: 13 page
The Mass-Metallicity relation explored with CALIFA: I. Is there a dependence on the star formation rate?
We present the results on the study of the global and local M-Z relation
based on the first data available from the CALIFA survey (150 galaxies). This
survey provides integral field spectroscopy of the complete optical extent of
each galaxy (up to 2-3 effective radii), with enough resolution to separate
individual HII regions and/or aggregations. Nearly 3000 individual HII
regions have been detected. The spectra cover the wavelength range between
[OII]3727 and [SII]6731, with a sufficient signal-to-noise to derive the oxygen
abundance and star-formation rate associated with each region. In addition, we
have computed the integrated and spatially resolved stellar masses (and surface
densities), based on SDSS photometric data. We explore the relations between
the stellar mass, oxygen abundance and star-formation rate using this dataset.
We derive a tight relation between the integrated stellar mass and the
gas-phase abundance, with a dispersion smaller than the one already reported in
the literature (0.07 dex). Indeed, this
dispersion is only slightly larger than the typical error derived for our
oxygen abundances. However, we do not find any secondary relation with the
star-formation rate, other than the one induced due to the primary relation of
this quantity with the stellar mass. We confirm the result using the 3000
individual HII regions, for the corresponding local relations.
Our results agree with the scenario in which gas recycling in galaxies, both
locally and globally, is much faster than other typical timescales, like that
of gas accretion by inflow and/or metal loss due to outflows. In essence,
late-type/disk dominated galaxies seem to be in a quasi-steady situation, with
a behavior similar to the one expected from an instantaneous
recycling/closed-box model.Comment: 19 Pages, 8 figures, Accepted for Publishing in Astronomy and
Astrophysics (A&A
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